I haven't done a "Five for Friday" in a bit so here we go:
On Being - some highly intelligent conversations around big issues
WTF - Mark Moran, a comedian with some raunchy language but a great interview technique and interesting conversations
Here's the Thing - Alec Baldwin, yes, the actor who actually is more serious than how he usually appears
http://www.wnyc.org/shows/heresthething/ and dig into the archives to find his interview with Billy Joel - priceless!
RadioLab - explores the scientific side of things in interesting ways, with shorts and longer podcasts. Only issue is that it not as frequently published as I would like
And for something not yet available other than via a weekly email, the MondayMorningMemo - yes, once a week, religiously on Monday's